解决文献不多的问题——以PCNP与脑血栓为例

检索方式：高级检索/Title and abstract

一、Nuclear protein/NP

1.NP and 血栓thrombus---2篇：

https://pubmed.ncbi.nlm.nih.gov/?term=%28nuclear+protein%5BTitle%2FAbstract%5D%29+AND+%28thrombus%5BTitle%2FAbstract%5D%29&sort=date

1: Tang P, Liu H, Lin B, Yang W, Chen W, Lu Z, Li P, Gui S, Zhan Y, Lin B. Spatholobi Caulis dispensing granule reduces deep vein thrombus burden through antiinflammation via SIRT1 and Nrf2. Phytomedicine. 2020 Oct;77:153285. doi:10.1016/j.phymed.2020.153285. Epub 2020 Jul 15. PMID: 32707369.

2: Ulfhammer E, Carlström M, Bergh N, Larsson P, Karlsson L, Jern S. Suppression of endothelial t-PA expression by prolonged high laminar shear stress. Biochem Biophys Res Commun. 2009 Feb 6;379(2):532-6. doi: 10.1016/j.bbrc.2008.12.105. Epub 2008 Dec 29. PMID: 19116134.

2.NP 与 脑Brain----686篇

https://pubmed.ncbi.nlm.nih.gov/?term=%28nuclear+protein%5BTitle%2FAbstract%5D%29+AND+%28brain%5BTitle%2FAbstract%5D%29&sort=date

3.NP 与 血管vessel---28篇

https://pubmed.ncbi.nlm.nih.gov/?term=%28nuclear+protein%5BTitle%2FAbstract%5D%29+AND+%28vessel%5BTitle%2FAbstract%5D%29&sort=date&size=200

4.NP与动脉artery---86篇

https://pubmed.ncbi.nlm.nih.gov/?term=%28nuclear+protein%5BTitle%2FAbstract%5D%29+AND+%28artery%5BTitle%2FAbstract%5D%29&sort=date&size=200

二、PEST与脑的关系：

2.1.PEST domain and brain----8篇

https://pubmed.ncbi.nlm.nih.gov/?term=%28PEST+domain%5BTitle%2FAbstract%5D%29+AND+%28brain%5BTitle%2FAbstract%5D%29&sort=date

1: Su P, Wu H, Wang M, Cai L, Liu Y, Chen LM. IRBIT activates NBCe1-B by releasing the auto-inhibition module from the transmembrane domain. J Physiol. 2021 Feb;599(4):1151-1172. doi: 10.1113/JP280578. Epub 2020 Dec 9. PMID: 33237573; PMCID: PMC7898672.

2: Arruga F, Gizdic B, Bologna C, Cignetto S, Buonincontri R, Serra S, Vaisitti T, Gizzi K, Vitale N, Garaffo G, Mereu E, Diop F, Neri F, Incarnato D, Coscia M, Allan J, Piva R, Oliviero S, Furman RR, Rossi D, Gaidano G, Deaglio S. Mutations in NOTCH1 PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22. Leukemia. 2017 Sep;31(9):1882-1893. doi: 10.1038/leu.2016.383. Epub 2016 Dec 26. PMID:28017968.

3: Yap MY, Lo YL, Talbot K, Ong WY. Oxidative stress reduces levels of dysbindin-1A via its PEST domain. Neurochem Int. 2014 Dec;79:65-9. doi: 10.1016/j.neuint.2014.10.001. Epub 2014 Oct 31. PMID: 25445987.

4: Santos MS, Foss SM, Park CK, Voglmaier SM. Protein interactions of the vesicular glutamate transporter VGLUT1. PLoS One. 2014 Oct 15;9(10):e109824. doi: 10.1371/journal.pone.0109824. PMID: 25334008; PMCID: PMC4198130.

5: Arjona FJ, de Vrieze E, Visser TJ, Flik G, Klaren PH. Identification and functional characterization of zebrafish solute carrier Slc16a2 (Mct8) as a thyroid hormone membrane transporter. Endocrinology. 2011 Dec;152(12):5065-73. doi: 10.1210/en.2011-1166. Epub 2011 Sep 27. PMID: 21952246.

6: Nelson RF, Glenn KA, Miller VM, Wen H, Paulson HL. A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control. J Biol Chem. 2006 Jul 21;281(29):20242-51. doi: 10.1074/jbc.M602423200. Epub 2006 May 8. PMID: 16682404.

7: Sacchi N, Tamanini F, Willemsen R, Denis-Donini S, Campiglio S, Hoogeveen AT. Subcellular localization of the oncoprotein MTG8 (CDR/ETO) in neural cells. Oncogene. 1998 May;16(20):2609-15. doi: 10.1038/sj.onc.1201824. PMID: 9632137.

8: Siman R, Card JP, Davis LG. Proteolytic processing of beta-amyloid precursor by calpain I. J Neurosci. 1990 Jul;10(7):2400-11. doi: 10.1523/JNEUROSCI.10-07-02400.1990. PMID: 2115911; PMCID: PMC6570374.

2.2.PESTsequenceand brain----7篇

https://pubmed.ncbi.nlm.nih.gov/?term=%28pest+sequence%5BTitle%2FAbstract%5D%29+AND+%28brain%5BTitle%2FAbstract%5D%29&sort=date

1: Zhao M, Jiang K, Song W, Ma C, Wang J, Meng Y, Wei H, Chen K, Qiao Z, Zhang F, Ma L. Two transcripts of HMG-CoA reductase related with developmental regulation from Scylla paramamosain: Evidences from cDNA cloning and expression analysis. IUBMB Life. 2015 Dec;67(12):954-65. doi: 10.1002/iub.1452. Epub 2015 Nov 24. PMID: 26601917.

2: Zhang WQ, Gong YF, Zhang L, Li J, Liu XD. [Cloning and expression analysis of the NFκB inhibitor IκBα of ayu (Plecoglossus altivelis)]. Dongwuxue Yanjiu. 2013 Aug;34(4):399-405. Chinese. doi: 10.11813/j.issn.0254-5853.2013.4.0399. PMID: 23913891.

3: Wenzel JJ, Kaminski WE, Piehler A, Heimerl S, Langmann T, Schmitz G. ABCA10, a novel cholesterol-regulated ABCA6-like ABC transporter. Biochem Biophys Res Commun. 2003 Jul 11;306(4):1089-98. doi: 10.1016/s0006-291x(03)01097-0. PMID: 12821155.

4: Shearn CT, Walker J, Norris FA. Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene. Biochem Biophys Res Commun. 2001 Aug 10;286(1):119-25. doi: 10.1006/bbrc.2001.5331. PMID: 11485317.

5: Nakamura T, Sanokawa R, Sasaki YF, Ayusawa D, Oishi M, Mori N. Cyclin I: a new cyclin encoded by a gene isolated from human brain. Exp Cell Res. 1995 Dec;221(2):534-42. doi: 10.1006/excr.1995.1406. PMID: 7493655.

6: Bierkamp C, Campos-Ortega JA. A zebrafish homologue of the Drosophila neurogenic gene Notch and its pattern of transcription during early embryogenesis. Mech Dev. 1993 Oct;43(2-3):87-100. doi: 10.1016/0925-4773(93)90027-u. PMID: 8297791.

7: Szkutnicka K, Tschopp JF, Andrews L, Cirillo VP. Sequence and structure of the yeast galactose transporter. J Bacteriol. 1989 Aug;171(8):4486-93. doi: 10.1128/jb.171.8.4486-4493.1989. PMID: 2666404; PMCID: PMC210229.

2.3.PEST motif and brain----2篇

https://pubmed.ncbi.nlm.nih.gov/?term=%28pest+motif%5BTitle%2FAbstract%5D%29+AND+%28brain%5BTitle%2FAbstract%5D%29&sort=date&size=200

1: Spencer ML, Theodosiou M, Noonan DJ. NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif. J Biol Chem. 2004 Aug 27;279(35):37069-78. doi: 10.1074/jbc.M402507200. Epub 2004 Jun 30. PMID: 15229225.

2: Kim YW, Wang H, Sures I, Lammers R, Martell KJ, Ullrich A. Characterization of the PEST family protein tyrosine phosphatase BDP1. Oncogene. 1996 Nov 21;13(10):2275-9. PMID: 8950995.

三、PCNP与脑的大数据结果：

Human protein atlas网站：

https://www.proteinatlas.org/search/PCNP