滕铁山

（信息截至2021年9月30日）

1、个人简介：

滕铁山，男， 1985 年12 月出生，校聘副教授。2015年7月毕业于中国科学院武汉病毒研究所，获博士学位。2015年9月至今工作于河南大学医学院病理学教研室，主要承担病理学教学工作。

2、主要研究方向：病原生物、噬菌体

3、承担的研究项目：

（1）2016-2018，河南省高等学校重点科研项目，主持，《微生物来源天然产物的分离、鉴定及抗结核活性分析》

（2）2017-2019，河南省重点研发与推广专项，主持，《天然产物PantocinWH-1的抗结核菌活性及其分子机制研究》

4、已发表论文： 

一、 发表论文（第一作者或通讯作者）

(1).Teng TS, Ji AL, Ji XY, Li YZ. Neutrophils and Immunity: From Bactericidal Action to Being Conquered. J Immunol Res. 2017;2017:9671604.

(2).Teng T, Xie L, Xie J. [Development of new anti-tuberculosis drugs: the strategy of unconventional microbial culture and silencing gene activation]. Sheng Wu Gong Cheng Xue Bao. 2018 Aug 25;34(8):1306-1315.chinese

(3).Teng T, Li Q, Liu Z, Li X, Liu Z, Liu H, Liu F, Xie L, Wang H, Zhang L, Wu D, Chen M, Li Y, Ji A. Characterization and genome analysis of novel Klebsiella phage Henu1 with lytic activity against clinical strains of Klebsiella pneumoniae. Arch Virol. 2019 Sep;164(9):2389-2393.

(4).Teng T, Liu J, Wei H. Anti-mycobacterial peptides: from human to phage. Cell Physiol Biochem. 2015;35(2):452-66. doi: 10.1159/000369711. Epub 2015 Jan 15.

(5).Teng T, Li X, Zhang L, Li Y. Identification and Characterization of pantocin wh-1, a Novel Cyclic Polypeptide Produced by Pantoea dispersa W18. Molecules. 2020 Jan 23;25(3):485.

(6).Teng T, Zhang G, Fan X, Zhang Z, Zhang L, Wu D, Chen S, Li Y, Jin J. Complete genome sequence analysis of PS2, a novel T4-like bacteriophage that infects Serratia marcescens clinical isolates. Arch Virol. 2018 Jul;163(7):1997-2000.

(7).Teng T, Yu J, Yang H, Wei H. Isolation and complete genome sequence of a novel virulent mycobacteriophage, CASbig. Virol Sin. 2015 Feb;30(1):76-9.

(8).Teng TS, Wang HH, Xie JP. [Advances in the study of Mycobacterium tuberculosis protein phosphatase and its inhibitors]. Yao Xue Xue Bao. 2011 Dec;46(12):1420-8. Chinese.（中文）

(9).Teng T , Wu D , Wang G . Using Information Technology to Integrate Pathology Course and Information Literacy as Part of Instruction[C]// 2016 8th International Conference on Information Technology in Medicine and Education (ITME). IEEE Computer Society, 2017.

(10).Teng T, Xianghui L, Bai H , et al. Exploration of Research-Oriented Microbiology Teaching Model: Taking Mycobacteriophage Isolation as Example[C]// 2018 9th International Conference on Information Technology in Medicine and Education (ITME). IEEE Computer Society, 2018.

(11).Fan X†, Teng T† , Wang H, Xie J. Biology of a novel mycobacteriophage, SWU1, isolated from Chinese soil as revealed by genomic characteristics. J Virol. 2012 Sep;86(18):10230-1. (co-first author)

(12).Wang G, Li X, Zhang L, Elgaili Abdalla A, Teng T*, Li Y. Crosstalk between Dendritic Cells and Immune Modulatory Agents against Sepsis. Genes (Basel). 2020 Mar 18;11(3):323. doi: 10.3390/genes11030323. PMID: 32197507; PMCID: PMC7140865.

(13).Wang G, Cai L, Chen D, Teng T*, Li Q, Xie L. Influence of COVID-19 in patients with concurrent tuberculosis coinfections. J Med Virol. 2021 Apr;93(4):1937-1939.

(14).Li, W. U. , Si, J. , Qiu, S. , Luo, J. , & Teng, T*. . (2020). Gp30 of the mycobacteriophage casbig impairs mycobacterial adaptation during acidic stress and in macrophages. BIOCELL, 1-7

(15)Li, X. , Hu, T. , Wei, J. , He, Y. , & Teng, T*. . (2021). Characterization of a novel bacteriophage henu2 and evaluation of the synergistic antibacterial activity of phage-antibiotics. Antibiotics, 10(2), 174.

(16).Li X, He Y, Wang Z, Wei J, Hu T, Si J, Tao G, Zhang L, Xie L, Abdalla AE, Wang G, Li Y, Teng T*. A combination therapy of Phages and Antibiotics: Two is better than one. Int J Biol Sci 2021; 17(13):3573-3582. doi:10.7150/ijbs.60551.

非第一作者文章发表：

(17) Dongdong Wu, Honggang Wang, Tieshan Teng, Shaofeng Duan, Ailing Ji, Yanzhang Li；Hydrogen sulfide and autophagy: A double edged sword，Accepted 2 March 2018

(18) Lei Zhang, Wen Liu, Qun Wang, Qinpei Li，Huijuan Wang，Jun Wang，Tieshan Teng, Mingliang Chen  Ailing Ji, and Yanzhang Li，New Drug Candidate Targeting the 4A1 OrphanNuclear Receptor for Medullary Thyroid Cancer Therapy Accepted 2 March 2018

(19) Xu, J.; Zhao, S.; Teng, T.; Abdalla, A. E.; Zhu, W.; Xie, L.; Wang, Y.; Guo, X., Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV. Viruses 2020, 12, (2).

(20) Wu, D.; Li, M.; Gao, Y.; Tian, W.; Li, J.; Zhang, Q.; Liu, Z.; Zheng, M.; Wang, H.; Wang, J.; Teng, T.; Zhang, L.; Ji, X.; Xie, Z.; Ji, A.; Li, Y., Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway. Journal of Cancer 2019, 10, (7), 1693-170

(21)Wu, D.; Liu, Z.; Li, J.; Zhang, Q.; Zhong, P.; Teng, T.; Chen, M.; Xie, Z.; Ji, A.; Li, Y., Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway. Cancer cell international 2019, 19, 43.

5、已授权专利

（1） 《一株能够产生细菌素的分散泛菌及其筛选方法和应用》专利编号：201410777726；发明人：危宏平; 滕铁山#; 杨航; 余军平;

（2） 《外泌体、其制备方法及其在制备治疗肺癌的药物中的应用》专利编号：201710285865.0贺飞，李涛，张凡，李振华，杨乐，吴东栋，滕铁山，姬新颖

6、已获批基金

(1)   2016-2018，河南省教育厅高等学校重点科研项目，主持，《微生物来源天然产物的分离、鉴定及抗结核活性分析》

(2)  2019-2021， 河南省重点研发与推广专项（科技攻关），主持，《天然产物PantocinWH-1的抗结核菌活性及其分子机制研》

(3)  国家自然科学基金面上项目，31570096，原子力显微镜研究铜绿假单胞菌噬菌体的结合与感染，2016.01-2019.12，结项，参与

(4)  国家自然科学基金青年项目，31400126，噬菌体裂解酶细胞壁结合域抑制铜绿假单胞菌生物被膜形成的机理与应用，2015.01-2018.12，结项，参与

7、联系方式（邮箱等）：Tengtieshan@vip.henu.edu.cn