一、科研项目
1. 河南大学青年交叉基金项目，LINC00511调控miR-150-5p靶向CBS促进口腔鳞癌生长的作用及其分子机制，2023.06-2025.12，20万元，在研，主持。
二、论文发表
1. Dong-Dong Wu#, Sheng Jin#, Ruo-Xiao Cheng#, Wen-Jie Cai#,*, Wen-Long Xue#, Qing-Qing Zhang, Le-Jie Yang, Qi Zhu, Meng-Yao Li, Ge Lin, Yi-Zhen Wang, Xue-Pan Mu, Yu Wang, Igor Ying Zhang, Qi Zhang, Ying Chen, Sheng-Yang Cai, Bo Tan, Ye Li, Yun-Qian Chen, Pu-Juan Zhang, Chen Sun, Yue Yin, Ming-Jie Wang, Yi-Zhun Zhu, Bei-Bei Tao, Jia-Hai Zhou*, Wei-Xue Huang*, Yi-Chun Zhu*. Hydrogen sulfide functions as a micro-modulator bound at the copper active site of Cu/Zn-SOD to regulate the catalytic activity of the enzyme. Cell Rep. 2023;42:112750.
2. Da-Yong Wang#, Jing Zhang#, Hai-Xia Li#, Yan-Xia Zhang, Mi-Rong Jing, Chun-Bo Cai, Di Wang, Hui-Wen Qi, Yi-Zhen Wang, Hao-Jie Chen, Tao Li, Yuan-Kun Zhai*, Xin-Ying Ji*, Dong-Dong Wu*. Inhibition of endogenous hydrogen sulfide production suppresses the growth of nasopharyngeal carcinoma cells. Mol. Carcinog. 2023;62:652-664.
3. Zi-Hua Guo#, Saadullah Khattak#, Mohd Ahmar Rauf#, Mohammad Azam Ansari, Mohammad N. Alomary, Sufyan Razak, Chang-Yong Yang*, Dong-Dong Wu*, Xin-Ying Ji*. Role of Nanomedicine-Based Therapeutics in the Treatment of CNS Disorders. Molecules. 2023;28(3):1283.
4. Chuan-Hao Zhang#, Zhi-Liang Jiang#, Yuan Meng, Wen-Yan Yang, Xin-Yu Zhang, Yan-Xia Zhang, Saadullah Khattak, Xin-Ying Ji*, Dong-Dong Wu*. Hydrogen sulfide and its donors: Novel antitumor and antimetastatic agents for liver cancer. Cell. Signal. 2023:106:110628.
5. Hao-Jie Chen, Ke Li, Yang-Zhe Qin, Jing-Jing Zhou, Tao Li, Lei Qian, Chang-Yong Yang*, Xin-Ying Ji*, Dong-Dong Wu*. Recent advances in the role of endogenous hydrogen sulphide in cancer cells. Cell Prolif. 2023;56(9):e13449.
6. Hong-Gang Wang#, Di Wang#, Muhammad Sarfraz, Attia Afzal, Mi-Rong Jing, Yan-Xia Zhang, Chun-Bo Cai, Hui-Wen Qi, Hao-Jie Chen, Tao Li, Shui-Juan Hu, Hong-Xia Liu*, Xin-Ying Ji*, Dong-Dong Wu*. Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells. Transl. Oncol. 2023:38:101770.
7. Shao-Feng Duan#, Meng-Meng Zhang#, Qian Dong, Bo Yang, Wei Liu, Xin Zhang, Hai-Lan Yu, Shi-Hui Zhang, Nazeer Hussain Khan, Dong-Dong Wu*, Xiao-Ju Zhang*, Juan Cen*. A Water-Soluble Hydrogen Sulfide Donor Suppresses the Growth of Hepatocellular Carcinoma via Inhibiting the AKT/GSK-3 β/ β-Catenin and TGF- β/Smad2/3 Signaling Pathways. J. Oncol. 2023:2023:8456852.
8. Dong-Dong Wu#, Yasmine Ahmed Salah#, Ebenezeri Erasto Ngowi, Yan-Xia Zhang, Saadullah Khattak, Nazeer Hussain Khan, Yan Wang, Tao Li, Zi-Hua Guo, Yan-Mei Wang*, Xin-Ying Ji*. Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration. iScience. 2023;26(8):107321.
9. Saadullah Khattak, Mohd Ahmar Rauf, Yasir Ali, Muhammad Tufail Yousaf, Zhihui Liu*, Dong-Dong Wu*, Xin-Ying Ji*. The monkeypox diagnosis, treatments and prevention: A review. Front. Cell. Infect. Microbiol. 2023:12:1088471.
10. Yan-Xia Zhang, Mi-Rong Jing, Chun-Bo Cai, Shuai-Gang Zhu, Chao-Jing Zhang, Qi-Meng Wang, Yuan-Kun Zhai*, Xin-Ying Ji*, Dong-Dong Wu*. Cell Prolif. 2023;56(3):e13374.
11. Nazeer Hussain Khan#, Ebenezeri Erasto Ngowi#, Yan Li, Saadullah Khattak, Yingshuai Zhao, Muhammad Shahid, Ujala Zafar, Irum Waheed, Fatima Khan, Razia Virk, Istaqlal Hussain, Jiebin Cao, Hongxia Liu, Zhihui Liu*, Dong-Dong Wu*, and Xin-Ying Ji*. Hydrogen sulfide donors and inhibitors in cancer research: A state-of-the-art review. Gene & Protein in Disease. 2023; 2(1):164.
三、专利申请
1. 吴东栋，王怡禛，郑蒙，吴海刚，刘媛媛，司伟荣，敬米蓉，张艳霞，蔡春波，王迪，祁慧雯，张婧，李涛，李彦章，姬新颖，一种敲低CBS基因的方法及其在制备治疗人脑胶质瘤的药物中的应用，国家发明专利，专利号：ZL202110903988.2，授权。
四、学生培养
目前指导（含联合培养）在学研究生14名，2023年毕业3名硕士研究生。
五、科研奖励
1. 吴东栋，姬新颖，段少峰，王大勇，魏建设，含有PEST基序的核蛋白促进肿瘤生长的作用机制研究，河南省教育厅科技成果二等奖，河南省教育厅，2023.06
2. 吴东栋，李涛，王大勇，魏建设，姬新颖，PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways，河南省教育厅优秀科技论文奖二等奖，河南省教育厅，2023.06
3. 吴东栋，Epigallocatechin-3-Gallate Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via Inhibition of Apoptosis and Promotion of Autophagy through the ROS/MAPK Signaling Pathway，开封市自然科学优秀学术论文三等奖，开封市科学技术协会，2023.11
4. 吴东栋，Recent advances in the role of endogenous hydrogen sulphide in cancer cells，第八届中国转化医学大会暨中国精准医学大会青年优秀论文三等奖，中国转化医学大会暨中国精准医学大会，2023.10
六、学术兼职
河南省康复医学会智能装备与产品转化分会常委 2023.11
七、评审专家
浙江省自然科学基金评审专家 2023.07
河南省卫生健康科教专家 2023.05
开封市科技专家 2023.10
八、媒体报道
1. 口腔医学院召开春节留校学生慰问座谈会https://news.henu.edu.cn/info/1084/123116.htm
2. 口腔医学院召开主题教育研究生培养专题调研会https://news.henu.edu.cn/info/1084/124774.htm
3. 口腔医学院吴东栋教授带队赴开封市儿童医院开展座谈交流https://news.henu.edu.cn/info/1084/124583.htm
4. 复旦大学邵春林教授到口腔医学院座谈交流https://news.henu.edu.cn/info/1084/123276.htm
5. 首位外籍学者新加坡国立大学Gautam Sethi做客X+MIBS https://news.henu.edu.cn/info/1084/125030.htm
6. 我校基础医学院博士生Hussain Khan、Maria Mir论文入选高被引论文https://med.henu.edu.cn/info/1406/5343.htm
九、应邀报告
硫化氢调节肿瘤生长的作用机制研究，滑县人民医院，2023.12
