一、项目

1. 国家自然科学基金，81802718，CSE/H2S促进鼻咽癌生长的作用及其分子机制，2019/01-2021/12，20万元，结项，主持。

2. 河南省科技发展计划项目，202102310480，HA-ADT抑制食管癌生长的分子机制研究，2020/01-2021/12，结项，主持。

3. 河南省科技发展计划项目，192102310151，TIPE2介导直肠癌细胞生长的作用及分子机制，2019/01-2020/12，10万元，结项，第一参与人。

二、论文

1. Zhang YX, Jing MR, Cai CB, Zhu SG, Zhang CJ, Wang QM, Zhai YK*, Ji XY*, Wu DD*. Role of hydrogen sulphide in physiological and pathological angiogenesis. Cell Prolif. 2022 Dec 7:e13374.

2. Zhang Q^#, Gao Y^#, Zhang Y, Jing M, Wang D, Wang Y, Khattak S, Qi H, Cai C, Zhang J, Ngowi EE, Khan NH, Li T, Ji A, Jiang Q, Ji X*, Li Y*, Wu D*. Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma. Oncogene. 2022 Dec;41(49):5238-5252.

3. Khattak S, Idrees M, Iqbal HI, Khan M, Assad N, Khan MN, Yousaf MT, Farooq M, Yang CY*, Wu DD*, Ji XY*. Assessment of Attitudes and Intentions towards COVID-19 Vaccines and Associated Factors among General Populations of Pakistan: A Cross-Sectional Study. Vaccines (Basel). 2022 Sep 21;10(10):1583.

4. Wang J*, Li M, Geng Z, Khattak S, Ji X, Wu D*, Dang Y*. Role of Oxidative Stress in Retinal Disease and the Early Intervention Strategies: A Review. Oxid Med Cell Longev. 2022 Oct 14;2022:7836828.

5. Yang Y, Wang G, Zhang S, Wang H, Zhou W, Ren F, Liang H, Wu D, Ji X, Hashimoto M, Wei J*. Efficacy and evaluation of therapeutic exercises on adults with Parkinson's disease: a systematic review and network meta-analysis. BMC Geriatr. 2022 Oct 21;22(1):813.

6. Duan SF^#, Zhang MM^#, Zhang X, Liu W, Zhang SH, Yang B, Dong Q, Han JG, Yu HL, Li T, Ji XY*, Wu DD*, Zhang XJ*. HA-ADT suppresses esophageal squamous cell carcinoma progression via apoptosis promotion and autophagy inhibition. Exp Cell Res. 2022 Nov 1;420(1):113341.

7. Chen YG^#, Liu HX^#, Hong Y, Dong PZ, Liu SY, Gao YR, Lu D, Li T, Wang DY*, Wu DD*, Ji XY*. PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer. Int J Biol Sci. 2022 May 16;18(9):3605-3620.

8. Khan NH, Wang D, Wang W, Shahid M, Khattak S, Ngowi EE, Sarfraz M, Ji XY*, Zhang CY*, Wu DD*. Pharmacological Inhibition of Endogenous Hydrogen Sulfide Attenuates Breast Cancer Progression. Molecules. 2022 Jun 23;27(13):4049.

9. Zhao H, Liu H, Yang Y, Lan T, Wang H*, Wu D*. Hydrogen Sulfide Plays an Important Role by Regulating Endoplasmic Reticulum Stress in Diabetes-Related Diseases. Int J Mol Sci. 2022 Jun 28;23(13):7170.

10. Khattak S, Faheem M, Nawaz B, Khan M, Khan NH, Ullah N, Khan TA, Khan RU, Haleem KS, Ren ZG*, Wu DD*, Ji XY*. Knowledge, Attitude, and Perception of Cancer Patients towards COVID-19 in Pakistan: A Cross-Sectional Study. Int J Environ Res Public Health. 2022 Jun 28;19(13):7926.

11. Jiang QY, Li JM, Jing MR, Zhang YX, Zhang QQ, Cai CB, Wang D, Qi HW, Li T, Li YZ*, Ji XY*, Wu DD*. Cystathionine β-Synthase Regulates the Proliferation, Migration, and Invasion of Thyroid Carcinoma Cells. Oxid Med Cell Longev. 2022 Jun 27;2022:8678363.

12. Khattak S, Rauf MA, Khan NH, Zhang QQ, Chen HJ, Muhammad P, Ansari MA, Alomary MN, Jahangir M, Zhang CY*, Ji XY*, Wu DD*. Hydrogen Sulfide Biology and Its Role in Cancer. Molecules. 2022 May 25;27(11):3389.

13. Lu X, Huang H, Fu X, Chen C, Liu H, Wang H*, Wu D*. The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasome in Liver Disorders. Int J Mol Sci. 2022 Mar 24;23(7):3528.

14. Khan NH, Chen HJ, Fan Y, Surfaraz M, Ahammad MF, Qin YZ, Shahid M, Virk R, Jiang E*, Wu DD*, Ji XY*. Biology of PEST-Containing Nuclear Protein: A Potential Molecular Target for Cancer Research. Front Oncol. 2022 Feb 4;12:784597.

15. Liao Y^#, Fan Y^#, He Q, Li Y, Wu D*, Jiang E*. Exogenous H2S Ameliorates High Salt-Induced Hypertension by Alleviating Oxidative Stress and Inflammation in the Paraventricular Nucleus in Dahl S Rats. Cardiovasc Toxicol. 2022 May;22(5):477-491.

16. Wu DD^#, Ngowi EE^#, Zhai YK, Wang YZ, Khan NH, Kombo AF, Khattak S, Li T, Ji XY*. Role of Hydrogen Sulfide in Oral Disease. Oxid Med Cell Longev. 2022 Jan 25;2022:1886277.

三、专利

1. 吴东栋，钱蕾，梁晗，秦仰哲，李可，陈昊杰，周静静，姬新颖，一种过表达PCNP基因的方法及其在治疗人肝癌中的应用，国家发明专利，专利号：ZL202110432507.4，授权。

四、获奖

1. 吴东栋，段少峰，姬新颖等，硫化氢调节肿瘤生长的作用机制研究，河南省自然科学三等奖，河南省科技厅，2022.10

2. 吴东栋，段少峰，姬新颖等，硫化氢调节肿瘤生长的作用机制研究，河南省教育厅科技成果一等奖，河南省教育厅，2022.06

3. 吴东栋，吉爱玲，李彦章等，Exogenous hydrogen sulfide regulates the growth of human thyroid carcinoma cells，河南省教育厅优秀科技论文奖一等奖，河南省教育厅，2022.06

4. 吴东栋，Hydrogen Sulfide Attenuates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Inhibiting Apoptosis and Promoting Autophagy via Reactive Oxygen Species/Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin Signaling Pathway，开封市自然科学优秀学术论文一等奖，开封市科学技术协会，2022.09

五、学术兼职

开封市科技创新人才。

六、研究生培养

招收2名硕士研究生，毕业2名硕士研究生。