2021年工作总结

一、项目

1. 国家自然科学基金，81802718，CSE/H2S促进鼻咽癌生长的作用及其分子机制，2019/01-2021/12，20万元，结项，主持。

2. 河南省科技发展计划项目，202102310480，HA-ADT抑制食管癌生长的分子机制研究，2020/01-2021/12，结项，主持。

3. 河南省科技发展计划项目，192102310151，TIPE2介导直肠癌细胞生长的作用及分子机制，2019/01-2020/12，10万元，结项，第一参与人。

4. 河南省科技发展计划项目，192102310321，硫化氢通过增强自噬减轻肾脏缺血再灌注损伤的分子机制，2019/01-2020/12，10万元，结项，第二参与人。

二、论文

1. Nazeer Hussain Khan^#, Maria Mir^#, Lei Qian, Mahnoor Baloch, Muhammad Farhan Ali Khan, Asim-ur- Rehman, Ebenezeri Erasto Ngowi, Dong-Dong Wu*, Xin-Ying Ji*. Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures. J. Adv. Res. 16 June 2021, doi.org/10.1016/j.jare.2021.06.014.

2. Saadullah Khattak^#, Qian-Qian Zhang^#, Muhammad Sarfraz, Pir Muhammad, Ebenezeri Erasto Ngowi, Nazeer Hussain Khan, Saqib Rauf, Yi-Zhen Wang, Hui-Wen Qi, Di Wang, Attia Afzal*, Xin-Ying Ji*, Dong-Dong Wu*. The Role of Hydrogen Sulfide in Respiratory Diseases. Biomolecules 2021;11(5):682.

3. Saadullah Khattak, Mohd Ahmar Rauf, Qamar Zaman, Yasir Ali, Shabeen Fatima, Pir Muhammad, Tao Li, Hamza Ali Khan, Azhar Abbas Khan, Ebenezeri Erasto Ngowi, Dong-Dong Wu*, Xin-Ying Ji*. Genome-Wide Analysis of Codon Usage Patterns of SARS-CoV-2 Virus Reveals Global Heterogeneity of COVID-19. Biomolecules 2021;11(6):912.

4. Yasmeen Ahmed Salaheldin, Salma Sayed Mohamed Mahmoud, Ebenezeri Erasto Ngowi, Vivian Aku Gbordzor, Tao Li, Dong-Dong Wu*, Xin-Ying Ji*. Role of RONS and eIFs in Cancer Progression. Oxid. Med. Cell. Longev. 2021;2021:5522054.

5. Hao-Jie Chen, Ebenezeri Erasto Ngowi, Lei Qian, Tao Li, Yang-Zhe Qin, Jing-Jing Zhou, Ke Li, Xin-Ying Ji*, Dong-Dong Wu*. Role of Hydrogen Sulfide in the Endocrine System. Front. Endocrinol. 2021;12:704620.

6. Nazeer Hussain Khan, Maria Mir, Ebenezeri Erasto Ngowi, Ujala Zafar, Muhammad Mahtab Aslam Khan Khakwani, Saad Ullah Khatak, Yuan-Kun Zhai, En-She Jiang, Meng Zheng, Shao‐Feng Duan, Jian-She Wei, Dong-Dong Wu*, Xin-Ying Ji*. Nanomedicine: A Promising Way to Manage Alzheimer’s Disease. Front. Bioeng. Biotechnol. 2021;9:630055.

7. Dongdong Wu, Zhengguo Liu, Yizhen Wang, Qianqian Zhang, Jianmei Li, Peiyu Zhong, Zhongwen Xie*, Ailing Ji *, Yanzhang Li*. Epigallocatechin-3-Gallate Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via Inhibition of Apoptosis and Promotion of Autophagy through the ROS/MAPK Signaling Pathway. Oxid. Med. Cell. Longev. 2021;2021,5599997.

8. Ebenezeri Erasto Ngowi^#, Yi-Zhen Wang^#, Saadullah Khattak, Nazeer Hussain Khan, Salma Sayed Mohamed Mahmoud, Yasmeen Ahmed Saleheldin Hassan Helmy, Qi-Ying Jiang, Tao Li, Shao-Feng Duan, Xin-Ying Ji*, Dong-Dong Wu*. Impact of the factors shaping gut microbiota on obesity. J. Appl. Microbiol. 2021;131(5):2131-2147.

9. Ebenezeri Erasto Ngowi^#, Yi-Zhen Wang^#, Lei Qian^#, Yasmen Ahmed Saleheldin Hassan Helmy, Bright Anyomi, Tao Li, Meng Zheng, En-She Jiang, Shao-Feng Duan, Jian-She Wei, Dong-Dong Wu*, Xin-Ying Ji*. The application of nanotechnology for the diagnosis and treatment of brain diseases and disorders. Front. Bioeng. Biotechnol. 2021;9:629832.

10. Yi-Zhen Wang^#, Ebenezeri Erasto Ngowi^#, Di Wang, Hui-Wen Qi, Mi-Rong Jing, Yan-Xia Zhang, Chun-Bo Cai, Qing-Lin He, Saadullah Khattak, Nazeer Hussain Khan, Qi-Ying Jiang*, Xin-Ying Ji*, Dong-Dong Wu*. The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases. Int. J. Mol. Sci. 2021, 22(4), 2194.

三、专利

1. 吴东栋，田文柯，李见梅，张倩倩，李彦章，陈明亮，王红钢，王慧娟，张磊，一种生物活性肽P11在治疗甲状腺癌的药物中效果分析方法，国家发明专利，专利号：ZL201810918855.0，授权。

2. 吴东栋，李涛，高荧苒，王大勇，陆丹，刘诗语，洪亚，魏建设，姬新颖，一种过表达PCNP基因的药物的制备及用途，国家发明专利，专利号：ZL201710824523.1，授权。

3. 张国瑜，李涛，吴东栋，赵琼，滕铁山，段少峰，姬新颖，一种基于干细胞源外泌体的组合物及其在制备治疗心肌梗死的药物中的应用，国家发明专利，专利号：ZL201710286101.3，授权。

四、获奖

1. 吴东栋，吉爱玲，李彦章等，硫化氢缓解肾脏损伤的作用机制研究，河南省教育厅科技成果二等奖，河南省教育厅，2021.5

2. 吴东栋，段少峰，魏建设等，Hydrogen Sulfide Alleviates Lipopolysaccharide- Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways，河南省教育厅优秀科技论文奖一等奖，河南省教育厅，2021.5

3. 吴东栋，河南大学2019-2020年度科研优秀奖，河南大学，2021.12

五、学会任职

担任河南省科学保健学会理事。

六、担任评委

担任浙江省自然科学基金评审专家。

七、研究生培养

招收2名硕士研究生，毕业2名硕士研究生，其中1名硕士毕业生到首都医科大学攻读博士学位。