一、PEST motif功能

1.PEST与细胞代谢酶;

2.PEST与转录因子;

3.PEST与蛋白激酶;

4.PEST与蛋白磷酸酶;

5.PEST与细胞周期蛋白;

6.PEST与细胞粘附;

7.PEST与细胞迁移;

8.PEST与细胞凋亡。

二、nuclear proteins与肿瘤

三、蛋白降解protein degradation与肿瘤

1.proteosome;

2.calpain.

四、核蛋白PCNP关联分子与肿瘤

1.NIRF与肿瘤的关系;

2.UHRF与肿瘤的关系;

3.其他分子。

五、PEST，nuclear proteins与肿瘤抑制

Review topics and research contents for nuclear protein PCNP

I.functions of PEST motif

1.PEST and cellular metabolic enzymes；

2.PEST and transcription；

3.PEST and protein kinases；

4.PEST and protein phosphatases；

5.PEST and cyclin；

6.PEST and cell adhesion；

7.PEST and cell migration；

8.PEST and apoptosis；

9.PEST and  ferroptosis;

10.PEST and cuproptosis;

11.PEST and autophagy;

12.PEST and pyroptosis;

II.nuclear proteins and cancer

III.PEST-related protein degradation in cancer

1.PEST and proteosome;

2.PEST and calpain;

IV. relationship of nuclear protein PCNP-related proteins and cancer

1.NIRF in cancer；

2.UHRF in cancer；

3.other proteins。

V.PEST,nuclear proteins and tumor suppression

VI. PCNP in different cancers