I.functions of PEST motif;

1.PEST and cellular metabolic enzymes；

2.PEST and transcription；

3.PEST and protein kinases；

4.PEST and protein phosphatases；

5.PEST and cyclin；

6.PEST and cell adhesion；

7.PEST and cell migration；

8.PEST and apoptosis；

9.PEST and ferroptosis;

10.PEST and cuproptosis;

11.PEST and autophagy;

12.PEST and pyroptosis;

II.nuclear proteins and cancer；

III.PEST-related protein degradation in cancer;

1.PEST and proteosome;

2.PEST and calpain;

IV. relationship of nuclear protein PCNP-related proteins and cancer.

1.NIRF in cancer；

2.UHRF in cancer；

3.other proteins。

V.PEST,nuclear proteins and tumor suppression.

VI. PCNP in different cancers.