一、项目
1. 河南省高等学校青年骨干教师培养计划项目，2020GGJS038，CBS/H2S 促进 甲状腺癌生长的分子机制，2021/01-2023/12，4万元，新增主持。
2. 河南省科技攻关项目，182102310335，PCNP介导神经母细胞瘤生长的作用 及分子机制，2018/01-2019/12，结项，主持。
3. 河南大学医学院青年人才科研培育计划项目，2019013，HA-ADT抑制食管癌 生长的作用及其分子机制，2019/06-2020/12，5万元，结项，主持。
4. 国家自然科学基金面上项目，基于TIPE2抑制的PCNP上调改善感染后膈肌无 力的分子机制，2017/06-2020/12，60万元，结项，第一参与人。
5. 河南省科技攻关项目，192102310080，新型神经肽spexin对炎症痛的镇痛效 应及分子机制研究，2019/01-2020/12，10万元，结项，第二参与人。
二、文章
1. Ebenezeri Erasto Ngowi, Attia Afzal, Muhammad Sarfraz, Saadullah Khattak, Shams Uz Zaman, Nazeer Hussain Khan, Tao Li, Qi-Ying Jiang, Xin Zhang, Shao-Feng Duan*, Xin-Ying Ji*, Dong-Dong Wu*. Role of hydrogen sulfide donors in cancer development and progression. Int J Biol Sci. 2021;17(1):73-88. (SCI 二区，IF：4.858)
2. Ebenezeri Erasto Ngowi, Muham Promoting Autophagy via Reactive Oxygen Species/Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin Signaling Pathway. Front Pharmacol. 2020; 11: 585860. (SCI二区，IF：4.225)
3. Pengzhen Dong, Hao Fu, Lin Chen, Shihui Zhang, Xin Zhang, Huimin Li*, Dongdong Wu*, Xinying Ji*. PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition. J. Cell. Mol. Med. 2020;24:8221-8235. (SCI二区，IF：4.486) 4. Dongdong Wu, Peiyu Zhong, Yizhen Wang, Qianqian Zhang, Jianmei Li, Zhengguo Liu, Ailing Ji*, Yanzhang Li*. Hydrogen Sulfide Attenuates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Inhibiting Apoptosis and Promoting Autophagy via Reactive Oxygen Species/Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin Signaling Pathway. Front Pharmacol. 2020; 11: 585860. (SCI二区，IF：4.225)
5.Muhammad Sarfraz# , Attia Afzal# , Saadullah Khattak# , Umair Ali Khan Saddozai, Hui-Min Li, Qian-Qian Zhang, Asadullah Madni, Kashif S. Haleem, Shao-Feng Duan*, Dong-Dong Wu*, Shao-Ping Ji*, Xin-Ying Ji*. Multifaceted behavior of PEST sequence enriched nuclear proteins in cancer biology and role in gene therapy. J Cell Physiol. 2021;236(3):1658-1676. (SCI二区，IF：5.546)
6. Yan-Jie Han#,*, Zhi-Guang Ren# , Xin-Xin Li, Ji-Liang Yan, Chun-Yan Ma, Dong-Dong Wu*, Xin-Ying Ji*. Advances and challenges in the prevention and treatment of COVID-19. Int. J. Med. Sci. 2020;17(12):1803-1810. (SCI三区，IF： 2.523)
7. Nazeer Hussain Khan, Faiz Ullah, Taskin Aman Khan, Ujala Zafar, Muhammad Farhan Ali Khan, Muhammad Mustaqeem, Syed Sakhawat Shah, Dong-Dong Wu*, Xin-Ying Ji*. Personal Care Cosmetic Practice in Pakistan: Current and Future Prospective. Clin Cosmet Investig Dermatol. 2020, accepted. (SCI四区， IF：1.97)
8. Nazeer Hussain Khan, Shao-Feng Duan, Dong-Dong Wu*, Xin-Ying Ji*. A Call for Better Reporting and Awareness Campaigns to Address the delay in Early Diagnose of Brest Cancer in Pakistani Women. Cancer Management and Research. 2020, accepted. (SCI三区，IF：2.886)
9. Lei Zhang, Wen Liu, Fangyan Liu, Qun Wang*, Mengjiao Song, Qi Yu, Kun Tang, Tieshan Teng, Dongdong Wu, Xijing Wang, Wuqi Han, Yanzhang Li*. IMCA induces ferroptosis mediated by SLC7A11 through the AMPK/mTOR pathway in colorectal cancer. Oxid. Med. Cell. Longev. 2020;2020:1675613. (SCI二区，IF： 5.076)
10. Qing Zhao, Yongqiang Li, Yanhong Li, Xinying Ji, Huimin Li, Dongdong Wu, Wenqiang Wei, Xinchun Wang*. Silencing EPB41 Gene Expression Leads to Cell Cycle Arrest, Migration Inhibition, and Upregulation of Cell Surface Antigen in DC2.4 Cells. Med. Sci. Monit. 2020;26:e920594. (SCI四区，IF：1.918)
11. 郭矗，吴东栋*，姬新颖*，硫化氢对脊髓损伤治疗的研究进展，中国生物化 学与分子生物学报，2020;36(2):159-164. (中国科技核心期刊)
12. 陆丹，魏望，沈艳丽，吴东栋*，姬新颖*. 新型冠状病毒对多种生理系统的 影响, 暨南大学学报，已接受。(中国科技核心期刊)
三、专利
1. 王红钢，吴东栋，葛振英，陈明亮，吕双瑜，聂小博，刘峰涛，王怡禛，5,6- 吲哚并二恶烷类衍生物及其制备方法和应用，国家发明专利，专利号： ZL201910412777.1，授权。
2. 贺飞，李涛，张凡，李振华，杨乐，吴东栋，滕铁山，姬新颖，外泌体、其 制备方法及其在制备治疗肺癌的药物中的应用，国家发明专利，专利号： ZL201710285865.0，授权。
3. 张磊，刘稳，黄永伟，李彦章，王慧娟，陈明亮，王群，刘芳艳，吴东栋， IMCA 在 制 备 抗 结 直 肠 癌 药 物 中 的 应 用 ，国家发明专利，专利号 ZL201711266998.X，授权。
四、获奖
1. 吴东栋，吉爱玲，李彦章等，硫化氢介导肝癌生长的作用机制研究，河南省 教育厅科技成果二等奖，河南省教育厅，2020.5
2. 吴东栋，吉爱玲，李彦章等，Hydrogen sulfide acts as a double-edged sword in human hepatocellular carcinoma cells through EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways，河南省教育厅优秀科技论文奖一等奖，河南 省教育厅，2020.5
3. 吴东栋，吉爱玲，李彦章等，Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways，河南省教育厅优秀科技论文奖一等奖，河南省教育厅， 2020.5
