滕铁山

一、个人简介：

滕铁山，博士，副教授，硕士生导师，开封市科技创新人才，国际期刊Gene & Protein in Disease编辑，中国转化医学会河南省科协评审咨询专家库入库专家。河南大学基础医学院研科办主任、寄生虫学教研室主任、外事秘书。2023年秋季学期，被选派挂职担任信阳职业技术学院医学院副院长。先后参与和主持国家自然科学基金、河南省重大科技专项、博士后自然科学基金项目，国家发明专利授权3项，主要研究方向为重大疾病生物学标志物研究，以通讯作者和第一作者发表SCI论文30余篇。以第一完成人获河南省教育厅科技成果奖优秀科技论文奖一等奖、开封市第十七届自然科学优秀学术成果奖-优秀论文一等奖各2项。获得河南大学教学质量竞赛二等奖，河南大学大学生创新创业训练计划项目优秀指导教师。担任河南省医学会委员、河南省免疫学会感染病与分子免疫学专业委员会委员。

二、学习工作经历

2012年9月-2015年7月，中国科学院武汉病毒研究所，博士

2015年9月-至今，河南大学基础医学院病理学教研室教师

2019年9月-至今，河南大学研究生支部书记、外事秘书

2021年7月-至今，河南大学基础医学院研科办主任，寄生虫教研室主任

三、主要研究方向：重大疾病分子标志物研究

四、承担的主要研究项目

1. 2016-2018，河南省教育厅高等学校重点科研项目，微生物来源天然产物的分离、鉴定及抗结核活性分析，3万元，主持

2. 河南省重点研发与推广专项（科技攻关），天然产物PantocinWH-1的抗结核菌活性及其分子机制研究，10万元，主持，2019/1-2021/12，

3.河南省重点研发与推广专项（科技攻关），基于 CRISPR/Cas 系统的快速检测结核分枝杆菌及其耐药性新方法的研究，10万元，2023/1-2024/12，主持，在研

4.国家自然科学基金面上项目，31570096，原子力显微镜研究铜绿假单胞菌噬菌体的结合与感染，2016.01-2019.12，结项，参与

5.国家自然科学基金青年项目，31400126，噬菌体裂解酶细胞壁结合域抑制铜绿假单胞菌生物被膜形成的机理与应用，2015.01-2018.12，结项，参与

6.河南省医学科技攻关计划项目，H₂S通过CMA降解PLIN2调控肝脏脂质代谢的机制及其在NAFLD治疗中的作用，LHGJ20250513，在研，参与

五、已发表论文：

一、 发表论文（第一作者或通讯作者）

(1).Teng TS, Ji AL, Ji XY, Li YZ. Neutrophils and Immunity: From Bactericidal Action to Being Conquered. J Immunol Res. 2017;2017:9671604.

(2).Teng T, Li Q, Liu Z, Li X, Liu Z, Liu H, Liu F, Xie L, Wang H, Zhang L, Wu D, Chen M, Li Y, Ji A. Characterization and genome analysis of novel Klebsiella phage Henu1 with lytic activity against clinical strains of Klebsiella pneumoniae. Arch Virol. 2019 Sep;164(9):2389-2393.

(3).Teng T, Liu J, Wei H. Anti-mycobacterial peptides: from human to phage. Cell Physiol Biochem. 2015;35(2):452-66. doi: 10.1159/000369711. Epub 2015 Jan 15.

(4).Teng T, Li X, Zhang L, Li Y. Identification and Characterization of pantocin wh-1, a Novel Cyclic Polypeptide Produced by Pantoea dispersa W18. Molecules. 2020 Jan 23;25(3):485.

(5).Teng T, Zhang G, Fan X, Zhang Z, Zhang L, Wu D, Chen S, Li Y, Jin J. Complete genome sequence analysis of PS2, a novel T4-like bacteriophage that infects Serratia marcescens clinical isolates. Arch Virol. 2018 Jul;163(7):1997-2000.

(6).Teng T, Yu J, Yang H, Wei H. Isolation and complete genome sequence of a novel virulent mycobacteriophage, CASbig. Virol Sin. 2015 Feb;30(1):76-9.

(7).Teng T , Wu D , Wang G . Using Information Technology to Integrate Pathology Course and Information Literacy as Part of Instruction[C]// 2016 8th International Conference on Information Technology in Medicine and Education (ITME). IEEE Computer Society, 2017.

(8).Teng T, Xianghui L, Bai H , et al. Exploration of Research-Oriented Microbiology Teaching Model: Taking Mycobacteriophage Isolation as Example[C]// 2018 9th International Conference on Information Technology in Medicine and Education (ITME). IEEE Computer Society, 2018.

(9).Teng, T., Qiu, S., Zhao, Y., Zhao, S., Sun, D., Hou, L., Li, Y., Zhou, K., Yu, X., Yang, C., & Li, Y. (2022). Pathogenesis and Therapeutic Strategies Related to Non-Alcoholic Fatty Liver Disease. International journal of molecular sciences, 23(14), 7841.

(10).Fan X†, Teng T† , Wang H, Xie J. Biology of a novel mycobacteriophage, SWU1, isolated from Chinese soil as revealed by genomic characteristics. J Virol. 2012 Sep;86(18):10230-1. (co-first author)

(11).Wang G, Li X, Zhang L, Elgaili Abdalla A, Teng T*, Li Y. Crosstalk between Dendritic Cells and Immune Modulatory Agents against Sepsis. Genes (Basel). 2020 Mar 18;11(3):323. doi: 10.3390/genes11030323. PMID: 32197507; PMCID: PMC7140865.

(12).Wang G, Cai L, Chen D, Teng T*, Li Q, Xie L. Influence of COVID-19 in patients with concurrent tuberculosis coinfections. J Med Virol. 2021 Apr;93(4):1937-1939.

(13).Li, W. U. , Si, J. , Qiu, S. , Luo, J. , & Teng, T*. . (2020). Gp30 of the mycobacteriophage casbig impairs mycobacterial adaptation during acidic stress and in macrophages. BIOCELL, 1-7

(14)Li, X. , Hu, T. , Wei, J. , He, Y. , & Teng, T*. . (2021). Characterization of a novel bacteriophage henu2 and evaluation of the synergistic antibacterial activity of phage-antibiotics. Antibiotics, 10(2), 174.

(15).Li X, He Y, Wang Z, Wei J, Hu T, Si J, Tao G, Zhang L, Xie L, Abdalla AE, Wang G, Li Y, Teng T*. A combination therapy of Phages and Antibiotics: Two is better than one. Int J Biol Sci 2021; 17(13):3573-3582. doi:10.7150/ijbs.60551.

(16) Li, X., Zhang, Y., He, L., Si, J., Qiu, S., He, Y., Wei, J., Wang, Z., Xie, L., Li, Y., & Teng, T*. (2022). Immune response and potential therapeutic strategies for the SARS-CoV-2 associated with the COVID-19 pandemic. International journal of biological sciences, 18(5), 1865–1877.

(17) Li, X., Jiang, K., Ruan, Y., Zhao, S., Zhao, Y., He, Y., Wang, Z., Wei, J., Li, Q., Yang, C., Li, Y., & Teng, T*. (2022). Hydrogen Sulfide and Its Donors: Keys to Unlock the Chains of Nonalcoholic Fatty Liver Disease. International journal of molecular sciences, 23(20), 12202.

(18) Lv, S., Wang, Y., Jiang, K., Guo, X., Zhang, J., Zhou, F., Li, Q., Jiang, Y., Yang, C., & Teng, T*. (2023). Genetic Engineering and Biosynthesis Technology: Keys to Unlocking the Chains of Phage Therapy. Viruses, 15(8), 1736.

(19) Guo, X., Zhang, J., Wang, Y., Zhou, F., Li, Q., & Teng, T*. (2023). Phenotypic Characterization and Comparative Genomic Analyses of Mycobacteriophage WIVsmall as A New Member Assigned to F1 Subcluster. Current issues in molecular biology, 45(8), 6432–6448.

(20) Gao, M., Wang, Y., Zhuang, H., Zhu, Y., Chen, N., & Teng, T*. (2024). Insights into the Preparation of and Evaluation of the Bactericidal Effects of Phage-Based Hydrogels. International journal of molecular sciences, 25(17), 9472.

(21) Cheng, H., Deng, H., Ma, D., Gao, M., Zhou, Z., Li, H., Liu, S., & Teng, T*. (2024). Insight into the natural regulatory mechanisms and clinical applications of the CRISPR-Cas system. Heliyon, 10(20), e39538.

(22) Li, X., Xu, J., Wang, Y., Gomaa, S. E., Zhao, H., & Teng, T*. (2024). The Biological Characteristics of Mycobacterium Phage Henu3 and the Fitness Cost Associated with Its Resistant Strains. International journal of molecular sciences, 25(17), 9301.

(23) Zhao, J., Chen, B., Wang, W., Kang, Y., Hu, E., Zhang, Y., Chen, H., Xu, X., Ji, X., Wang, Y., Teng, T*., & Gomaa, S. E. (2024). Synergistic efficacy of phage Henu10 with antibiotics against Shigella dysenteriae with insight into phage resistance and fitness trade-offs. Frontiers in cellular and infection microbiology, 14, 1499325.

(24) Zhou, F., Wang, K., Ji, S., Liao, X., Zhang, W., Teng, T*., Wang, L., & Li, Q. (2025).The virulent bacteriophage Henu8 as an antimicrobial synergist against Escherichia coli. Microbiology spectrum, 13(7), e0163324.

(25) Li, Q., Li, J., Zhao, Y., Guo, S., Liu, M., Shi, X., Wang, L., Liu, Z., & Teng, T*. (2025). Characterization and genomics of phage Henu2_3 against K1 Klebsiella pneumoniae and its efficacy in animal models. AMB Express, 15(1), 112.

(26) Wang, X., Li, J., Ge, Z., Fan, J., Ma, D., Cao, H., Shen, J., Wang, Y., Liu, Z., Gomaa, S. E., Li, X., Ji, X., & Teng, T*. (2025). Phage therapy for intestinal infections: efficacy, challenges, and future directions in translational research. Frontiers in microbiology, 16, 1672198.

(27) Wang, X., Li, J., Ge, Z., Fan, J., Ma, D., Cao, H., Shen, J., Wang, Y., Liu, Z., Gomaa, S. E., Li, X., Ji, X., & Teng, T*. (2025). Phage therapy for intestinal infections: efficacy, challenges, and future directions in translational research. Frontiers in microbiology, 16, 1672198.

(28) Gomaa, S. E., Wang, Y., Li, J., Cao, H., Shen, J., Dong, X., Liu, Y., Chen, N., Li, Q., Yan, Z., Du, Y., Ji, X., Zhao, J., Tu, Y., & Teng, T*. (2025). Phage Henu12-resistant mutant derives fitness trade-offs in Shigella dysenteriae. Microbiology spectrum, 13(12), e0115025. Advance online publication.

(29) Zhang, Y., Shi, L., Zhou, F., Li, J., Liu, M., Guo, S., Shi, X., Zhang, X., Qiao, D., Zhang, J., Wang, K., Teng, T., Yuan, Y., Li, Q., & Wang, S. (2026). Characterization of the bacteriophage vB_KpnP_Henu1_3 lytic for K1 Klebsiella pneumoniae and its therapeutic efficacy in Galleria mellonella larvae and mice. Microbiology spectrum, e0093125. Advance online publication.

六、讲授课程：寄生虫学、病理学

七、联系方式（邮箱等）：Tengtieshan@henu.edu.cn